Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29237574 | 1.00 | AKR1C1 (0.49) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL4502888 | 0.87 | AKR1C1 (0.65) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL671822 | 0.87 | AKR1C1 (0.53) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL17632673 | 0.86 | AKR1C1 (0.62) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL1492825 | 0.84 | AKR1C1 (0.59) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL22832447 | 0.81 | AKR1C1 (0.43) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL30967898 | 0.80 | AKR1C1 (0.46) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL11832779 | 0.80 | AKR1C1 (0.46) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL14332444 | 0.80 | AKT1 (0.46) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 | |
| SCHEMBL29237470 | 0.80 | AKR1C1 (0.46) | AKR1C1ALDH1A1GAASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396179-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| CN-118201919-A | Indole compounds and methods of use | 健赞公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023034992-A1 | INDOLE COMPOUNDS AND METHODS OF USE | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |