Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221227 | 1.00 | HTR2A (0.64) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL29724224 | 0.95 | HTR2A (0.64) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL5496769 | 0.95 | HTR2A (0.64) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| Hydrochloric Acid SCHEMBL27261560 | 0.92 | HTR2A (0.61) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL15962624 | 0.89 | — | — | |
| SCHEMBL23188936 | 0.89 | HTR2A (0.53) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| Ammonia Solution, Strong SCHEMBL10465265 | 0.86 | HTR2A (0.67) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL5143608 | 0.81 | HTR2A (0.46) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL12430509 | 0.81 | HTR2A (0.46) | HTR2AHTR2CHTR2BPNMTKDM1A | |
| SCHEMBL16559360 | 0.79 | HTR2A (0.58) | HTR2AHTR2CHTR2BPNMTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392410-A1 | TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS FOR USE AS THERAPEUTICS | The University of British Columbia (CA) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023023853-A1 | TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS FOR USE AS THERAPEUTICS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2023-03-02 | — | — | WO | disclosed |