Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 15/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28986265 | 1.00 | MAP3K14 (0.50) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986302 | 0.84 | MAP3K14 (0.49) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986262 | 0.84 | MAP3K14 (0.49) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL30219568 | 0.84 | MAP3K14 (0.49) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986263 | 0.81 | MAPKAPK2 (0.56) | MAP3K14MAPKAPK2SRC | |
| SCHEMBL30219632 | 0.81 | MAPKAPK2 (0.56) | MAP3K14MAPKAPK2SRC | |
| SCHEMBL30219561 | 0.73 | MAP3K14 (0.50) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986271 | 0.73 | MAP3K14 (0.50) | MAP3K14MAPKAPK2PTK2CDC7CDK2 | |
| SCHEMBL28986246 | 0.71 | MAPKAPK2 (0.57) | MAP3K14MAPKAPK2CDC7CDK2ROCK1 | |
| SCHEMBL28986278 | 0.70 | MAPKAPK2 (0.56) | MAP3K14MAPKAPK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | disclosed |