Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | LCK | P06239 | 6/20 | 0.48 |
| ▸ | LYN | P07948 | 6/20 | 0.48 |
| ▸ | INSR | P06213 | 5/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.48 |
| ▸ | HCK | P08631 | 4/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 12/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13267797 | 0.90 | LCK (0.42) | KDRLCKLYNINSRSRC | |
| SCHEMBL3590408 | 0.88 | BRAF (0.47) | KDRLCKLYNINSRSRC | |
| SCHEMBL3019468 | 0.87 | BRAF (0.58) | KDRLCKLYNINSRSRC | |
| SCHEMBL3018850 | 0.87 | BRAF (0.54) | KDRLCKLYNINSRSRC | |
| SCHEMBL3021652 | 0.86 | POLB (0.59) | KDRLCKLYNINSRSRC | |
| SCHEMBL3004160 | 0.84 | BRAF (0.58) | KDRLCKLYNINSRSRC | |
| SCHEMBL3010076 | 0.83 | BRAF (0.52) | KDRLCKLYNINSRSRC | |
| SCHEMBL3003917 | 0.83 | MAP3K7 (0.65) | KDRLCKLYNINSRSRC | |
| SCHEMBL3021737 | 0.83 | MAP4K2 (0.44) | KDRLCKLYNINSRSRC | |
| SCHEMBL3022120 | 0.82 | BRAF (0.59) | LYNBRAFMAP3K7MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | claimed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | claimed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | claimed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | IRM LLC | 2010-07-22 | — | — | US | disclosed |
| EP-2170867-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157131-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184765-A1 | Protein Kinase Inhibitors and Methods for Using Thereof | BMX, FRK, FYN | KDR 182/4885LCK 8/4885LYN 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.