Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18965060 | 1.00 | GRIN2B (0.42) | GRIN2BEPHB4ALDH1A1GRIN1 | |
| SCHEMBL18965124 | 0.93 | EPHB4 (0.41) | GRIN2BEPHB4ALDH1A1GRIN1 | |
| SCHEMBL30219967 | 0.93 | EPHB4 (0.41) | GRIN2BEPHB4ALDH1A1GRIN1 | |
| SCHEMBL18964882 | 0.92 | EPHB4 (0.42) | GRIN2BEPHB4ALDH1A1GRIN1 | |
| SCHEMBL18964711 | 0.92 | GRIN2B (0.40) | GRIN2BALDH1A1 | |
| SCHEMBL30219973 | 0.92 | GRIN2B (0.40) | GRIN2BALDH1A1 | |
| SCHEMBL30219868 | 0.91 | GRIN2B (0.44) | GRIN2BEPHB4GRIN1 | |
| SCHEMBL18964497 | 0.91 | GRIN2B (0.44) | GRIN2BEPHB4GRIN1 | |
| SCHEMBL18965067 | 0.91 | EPHB4 (0.39) | GRIN2BEPHB4ALDH1A1GRIN1 | |
| SCHEMBL30220035 | 0.91 | EPHB4 (0.39) | GRIN2BEPHB4ALDH1A1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162890-B2 | Heteroaromatic NMDA receptor modulators and uses thereof | NOVARTIS AG (CH) | 2024-12-10 | — | — | US | disclosed |
| US-20230023543-A1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2023-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162890-B2 | Heteroaromatic NMDA receptor modulators and uses thereof | GRIN2C, GRIN2A, GRIN1 | GRIN2B 5/4885EPHB4 1894/4885ALDH1A1 1771/4885 |
| US-20230023543-A1 | HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN2C, GRIN2A, GRIN1 | GRIN2B 5/4885EPHB4 1894/4885ALDH1A1 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.