Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | IGF1R | P08069 | 2/20 | 0.62 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 6/20 | 0.46 |
| ▸ | CCNH | P51946 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24900456 | 1.00 | EGFR (0.62) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL24900457 | 0.91 | EGFR (0.54) | EGFRKCNH2IGF1R | |
| SCHEMBL31503148 | 0.91 | EGFR (0.54) | EGFRKCNH2IGF1R | |
| SCHEMBL24900787 | 0.91 | EGFR (0.58) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL24900731 | 0.90 | EGFR (0.54) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL30221619 | 0.90 | EGFR (0.54) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL24900802 | 0.90 | EGFR (0.65) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL30221514 | 0.89 | EGFR (0.50) | EGFRKCNH2IGF1R | |
| SCHEMBL24900801 | 0.88 | CDK7 (0.58) | EGFRKCNH2IGF1RCDK1KDR | |
| SCHEMBL24900836 | 0.85 | EGFR (0.59) | EGFRKCNH2IGF1RCDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023287783-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | ACEA Therapeutics, Inc. (US) | 2023-01-19 | — | — | WO | disclosed |