Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 10/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
| ▸ | MDM4 | O15151 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23993200 | 1.00 | PDE10A (0.36) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL23993201 | 0.84 | MTOR (0.36) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL30224597 | 0.84 | MTOR (0.36) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL23993138 | 0.83 | MTOR (0.36) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL23993993 | 0.79 | MDM2 (0.34) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL30224152 | 0.79 | MDM2 (0.34) | PDE10AMTORPIK3CDABL1EGFR | |
| SCHEMBL23991742 | 0.77 | MTOR (0.41) | MTORPIK3CDABL1EGFRHCK | |
| SCHEMBL23994710 | 0.77 | MTOR (0.38) | MTORPIK3CDABL1EGFRHCK | |
| SCHEMBL23991638 | 0.74 | MTOR (0.36) | MTORPIK3CDABL1EGFRHCK | |
| SCHEMBL22869353 | 0.74 | QPCT (0.33) | PDE10AMTORPIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |