Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23994516 | 1.00 | SYK (0.36) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL23991557 | 0.84 | MTOR (0.38) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL30224465 | 0.84 | MTOR (0.38) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL23992848 | 0.83 | MTOR (0.39) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL25005507 | 0.81 | MDM2 (0.38) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL30224213 | 0.80 | SYK (0.38) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL23994425 | 0.80 | SYK (0.38) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL23994741 | 0.79 | SYK (0.41) | SYKQPCTQPCTLCYP1A2 | |
| SCHEMBL23994473 | 0.79 | MTOR (0.39) | SYKPPARDQPCTQPCTLMTOR | |
| SCHEMBL29467431 | 0.78 | MTOR (0.34) | SYKPPARDQPCTQPCTLMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |