Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11977413 | 1.00 | PDPK1 (0.58) | PDPK1JAK2DYRK1AAXLCSNK2A1 | |
| SCHEMBL1758957 | 0.86 | PDPK1 (0.58) | PDPK1JAK2DYRK1AAXLCSNK2A1 | |
| SCHEMBL24358756 | 0.82 | PDPK1 (0.58) | PDPK1JAK2DYRK1AAXLCSNK2A1 | |
| SCHEMBL9980415 | 0.79 | MAP2K4 (0.44) | DYRK1AGSK3BERBB2NOS1 | |
| SCHEMBL29937465 | 0.79 | ITK (0.51) | ERBB2TTKMAPK1 | |
| SCHEMBL15942805 | 0.79 | ITK (0.51) | ERBB2TTKMAPK1 | |
| SCHEMBL16252839 | 0.79 | MAP2K4 (0.51) | ERBB2NTRK3MAPK1 | |
| SCHEMBL31621168 | 0.79 | MAP2K4 (0.44) | DYRK1AGSK3BERBB2NOS1 | |
| SCHEMBL27190999 | 0.78 | NTRK1 (0.34) | PDPK1JAK2GSK3BNTRK3TTK | |
| SCHEMBL2546465 | 0.75 | TTK (0.49) | GSK3BAURKBTTKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120157675-A | Pyrazolo six-membered ring derivative and application thereof in medicine | 海思科医药集团股份有限公司 | 2025-06-17 | — | — | CN | disclosed |
| WO-2024153112-A1 | PDE4 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 瑞石生物医药有限公司 | 2024-07-25 | — | — | WO | disclosed |
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |