⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411469 | 0.92 | — | — | |
| SCHEMBL2479 | 0.82 | — | — | |
| SCHEMBL596801 | 0.74 | — | — | |
| SCHEMBL4889883 | 0.67 | — | — | |
| SCHEMBL597073 | 0.63 | — | — | |
| SCHEMBL124259 | 0.63 | — | — | |
| SCHEMBL11853640 | 0.63 | CRBN (0.39) | — | |
| SCHEMBL1876971 | 0.62 | — | — | |
| SCHEMBL646639 | 0.61 | — | — | |
| SCHEMBL15238115 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 570 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4389738-A1 | SOS1 INHIBITOR AND USE THEREOF | Kanaph Therapeutics Inc. (KR) | 2024-06-26 | — | — | EP | claimed |
| CN-118119600-A | SOS1 inhibitors and uses thereof | 治纳辅医药科技有限公司 | 2024-05-31 | — | — | CN | claimed |
| US-20230219973-A1 | DEUBIQUITINASE INHIBITORS AND METHODS OF USE THEREOF | MOLECURE S.A. (PL) | 2023-07-13 | — | — | US | claimed |
| CN-110402248-B | Azaindoles as HPK1 inhibitors | 豪夫迈·罗氏有限公司 | 2023-01-06 | — | — | CN | claimed |
| US-11149040-B2 | Fused triazole agonists of the APJ receptor | AMGEN INC. (US) | 2021-10-19 | — | — | US | claimed |
| US-11046680-B1 | Heteroaryl-substituted triazoles as APJ receptor agonists | AMGEN INC. (US) | 2021-06-29 | — | — | US | claimed |
| US-10906890-B2 | Triazole phenyl compounds as agonists of the APJ receptor | AMGEN INC. (US) | 2021-02-02 | — | — | US | claimed |
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | claimed |
| EP-3541810-B1 | TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | claimed |
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | claimed |
| US-5922716-A | 5H-indeno 1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them | RHONE-POULENC RORER S.A. (FR) | 1999-07-13 | — | — | US | claimed |
| EP-0789699-B1 | SPIRO[HETEROCYCLE-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE]-4'-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE POULENC RORER SA (FR) | 1999-03-17 | — | — | EP | claimed |
| US-5807859-A | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | RHONE-POULENC RORER S.A. (FR) | 1998-09-15 | — | — | US | claimed |
| US-5789406-A | Indeno 1,2-E!pyrazine-4-ones, their preparation and the medicaments containing them | RHONE-POULENC RORER S.A. (FR) | 1998-08-04 | — | — | US | claimed |
| US-5777114-A | Spiro heterocycle-imidazo 1,2-a!indeno 1,2-e!pyrazine!-4'-ones, preparation thereof and drugs containing same | RHONE-POULENC RORER S.A. (FR) | 1998-07-07 | — | — | US | claimed |
| US-5726175-A | MULTISTAGE PROCESS WITH CYCLIZATION AND AMINATION | RHONE-POULENC RORER S.A. (FR) | 1998-03-10 | — | — | US | claimed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | claimed |
| EP-0175363-B1 | 4,5-DIHYDRO-3(2H)-PYRIDAZINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE | CASSELLA Aktiengesellschaft (DE) | 1990-01-17 | — | — | EP | claimed |
| US-4816454-A | CARDIOVASCULAR DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1989-03-28 | — | — | US | claimed |
| EP-0175363-A2 | 4,5-Dihydro-3(2H)-pyridazinones, process for their preparation and their use | CASSELLA Aktiengesellschaft (DE) | 1986-03-26 | — | — | EP | claimed |