Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.73 |
| ▸ | STAT3 | P40763 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | STAT1 | P42224 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25537140 | 0.94 | TYK2 (0.77) | TYK2JAK2 | |
| SCHEMBL30260243 | 0.91 | TYK2 (0.79) | TYK2STAT3JAK1 | |
| SCHEMBL30227261 | 0.89 | TYK2 (0.68) | TYK2STAT3JAK2JAK1STAT1 | |
| SCHEMBL25537143 | 0.85 | TYK2 (0.70) | TYK2JAK2 | |
| SCHEMBL30227241 | 0.84 | TYK2 (0.66) | TYK2STAT3JAK2JAK1STAT1 | |
| SCHEMBL25243773 | 0.84 | TYK2 (0.71) | TYK2STAT3JAK2JAK1STAT1 | |
| SCHEMBL30227271 | 0.84 | TYK2 (0.74) | TYK2STAT3JAK1 | |
| SCHEMBL23779231 | 0.84 | TYK2 (0.55) | TYK2STAT3JAK2JAK1STAT1 | |
| SCHEMBL30078825 | 0.84 | TYK2 (0.55) | TYK2STAT3JAK2JAK1STAT1 | |
| SCHEMBL30227528 | 0.83 | TYK2 (0.65) | TYK2STAT3JAK2JAK1STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143180-A1 | SUBSTITUTED N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE OR N-(METHYL-D3)-NICOTINAMIDE COMPOUNDS AS IL-12, IL-23 AND/OR IFNALPHA MODULATORS | Bristol-Myers Squibb Company (US) | 2023-03-08 | — | — | EP | claimed |
| CN-115715287-A | Substituted N- (methyl-d 3) pyridazine-3-carboxamide or N- (methyl-d 3) -nicotinamide compounds as IL-12, IL-23 and/or IFN alpha modulators | 百时美施贵宝公司 | 2023-02-24 | — | — | CN | claimed |
| EP-4143180-A1 | SUBSTITUTED N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE OR N-(METHYL-D3)-NICOTINAMIDE COMPOUNDS AS IL-12, IL-23 AND/OR IFNALPHA MODULATORS | Bristol-Myers Squibb Company (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-115715287-A | Substituted N- (methyl-d 3) pyridazine-3-carboxamide or N- (methyl-d 3) -nicotinamide compounds as IL-12, IL-23 and/or IFN alpha modulators | 百时美施贵宝公司 | 2023-02-24 | — | — | CN | disclosed |