Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.60 |
| ▸ | STAT3 | P40763 | 2/20 | 0.51 |
| ▸ | JAK1 | P23458 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25536922 | 0.94 | TYK2 (0.56) | TYK2JAK2 | |
| SCHEMBL28975910 | 0.88 | TYK2 (0.73) | TYK2STAT3JAK1JAK2STAT1 | |
| SCHEMBL25243773 | 0.87 | TYK2 (0.71) | TYK2STAT3JAK1JAK2STAT1 | |
| SCHEMBL30227249 | 0.86 | TYK2 (0.82) | TYK2STAT3JAK1JAK2STAT1 | |
| SCHEMBL15689104 | 0.86 | TYK2 (0.51) | TYK2 | |
| SCHEMBL23779211 | 0.85 | TYK2 (0.49) | TYK2STAT3JAK1JAK2STAT1 | |
| SCHEMBL24498562 | 0.81 | TYK2 (0.54) | TYK2STAT3JAK1JAK2JAK3 | |
| SCHEMBL29686520 | 0.81 | TYK2 (0.54) | TYK2STAT3JAK1JAK2JAK3 | |
| SCHEMBL25537207 | 0.81 | TYK2 (0.63) | TYK2JAK1JAK2CYP2C19 | |
| SCHEMBL20524882 | 0.81 | TYK2 (0.75) | TYK2STAT3JAK1JAK2STAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143180-A1 | SUBSTITUTED N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE OR N-(METHYL-D3)-NICOTINAMIDE COMPOUNDS AS IL-12, IL-23 AND/OR IFNALPHA MODULATORS | Bristol-Myers Squibb Company (US) | 2023-03-08 | — | — | EP | disclosed |