Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.72 |
| ▸ | JAK1 | P23458 | 7/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28975902 | 1.00 | TYK2 (0.72) | TYK2JAK1CYP2C19JAK2STAT3 | |
| SCHEMBL25536674 | 0.93 | TYK2 (0.63) | TYK2JAK1CYP2C19JAK2KCNH2 | |
| SCHEMBL25232915 | 0.87 | TYK2 (0.71) | TYK2JAK1CYP2C19STAT3 | |
| SCHEMBL30227307 | 0.87 | TYK2 (0.71) | TYK2JAK1CYP2C19STAT3 | |
| SCHEMBL30385114 | 0.87 | TYK2 (0.58) | TYK2JAK1CYP2C19JAK2STAT3 | |
| SCHEMBL24899716 | 0.86 | TYK2 (0.54) | TYK2JAK1CYP2C19JAK2KCNH2 | |
| SCHEMBL24498496 | 0.85 | TYK2 (0.54) | TYK2JAK1CYP2C19JAK2KCNH2 | |
| SCHEMBL29686474 | 0.85 | TYK2 (0.54) | TYK2JAK1CYP2C19JAK2KCNH2 | |
| SCHEMBL29686572 | 0.85 | TYK2 (0.72) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL28975941 | 0.84 | TYK2 (1.00) | TYK2JAK1CYP2C19STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143180-A1 | SUBSTITUTED N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE OR N-(METHYL-D3)-NICOTINAMIDE COMPOUNDS AS IL-12, IL-23 AND/OR IFNALPHA MODULATORS | Bristol-Myers Squibb Company (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-115715287-A | Substituted N- (methyl-d 3) pyridazine-3-carboxamide or N- (methyl-d 3) -nicotinamide compounds as IL-12, IL-23 and/or IFN alpha modulators | 百时美施贵宝公司 | 2023-02-24 | — | — | CN | disclosed |