Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 13/20 | 0.49 |
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK1 | P23458 | 9/20 | 0.49 |
| ▸ | JAK2 | O60674 | 8/20 | 0.49 |
| ▸ | PLK4 | O00444 | 6/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22055393 | 1.00 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL23878890 | 1.00 | TYK2 (0.49) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL24995883 | 0.89 | PLK4 (0.48) | TYK2JAK3JAK1JAK2PLK4 | |
| SCHEMBL22055066 | 0.85 | JAK3 (0.48) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23879074 | 0.85 | JAK3 (0.48) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878843 | 0.84 | TYK2 (0.56) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL22054963 | 0.84 | TYK2 (0.56) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878888 | 0.82 | JAK3 (0.48) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL23878886 | 0.82 | JAK3 (0.48) | TYK2JAK3JAK1JAK2P2RX3 | |
| SCHEMBL22056478 | 0.81 | RET (0.49) | TYK2JAK3JAK1JAK2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115925705-A | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-111511738-B | Heteroaromatic derivative regulator, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-01-20 | — | — | CN | disclosed |