Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 16/20 | 0.46 |
| ▸ | LCP2 | Q13094 | 6/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21990672 | 1.00 | MAP4K1 (0.46) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL25100230 | 0.86 | MAP4K1 (0.38) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL30232898 | 0.86 | MAP4K1 (0.38) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL30227903 | 0.85 | MAP4K1 (0.36) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL21990455 | 0.85 | MAP4K1 (0.36) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL21964197 | 0.84 | MAP4K1 (0.35) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL25099637 | 0.82 | MAP4K1 (0.37) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL30232971 | 0.81 | MAPK1 (0.36) | MAP4K1LCP2RPS6KA2PRKD2 | |
| SCHEMBL28975061 | 0.81 | KDM4A (0.35) | MAP4K1LCP2 | |
| SCHEMBL21964196 | 0.80 | MAP4K1 (0.33) | MAP4K1LCP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103369-A | Pyridolactam derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| WO-2023030478-A1 | PYRIDOLACTAM DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2023-03-09 | — | — | WO | disclosed |
| EP-4143186-A1 | AZALACTAM COMPOUNDS AS HPK1 INHIBITORS | Pfizer Inc. (US) | 2023-03-08 | — | — | EP | disclosed |