Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | IGLV6-57 | P01721 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227894 | 0.89 | KCNA3 (0.42) | KCNA3CA12CA9ALDH1A1KDM4E | |
| SCHEMBL30227885 | 0.89 | KCNA3 (0.42) | KCNA3CA12CA9ALDH1A1KDM4E | |
| SCHEMBL30228168 | 0.88 | KCNA3 (0.43) | KCNA3ALDH1A1KDM4EHTTLMNA | |
| SCHEMBL30228326 | 0.86 | KCNA3 (0.45) | KCNA3CA12CA9CA1ALDH1A1 | |
| SCHEMBL30228596 | 0.79 | IGLV6-57 (0.46) | KCNA3CA12CA9CA1ALDH1A1 | |
| SCHEMBL30228592 | 0.79 | KCNA3 (0.40) | KCNA3CA12CA9ALDH1A1KDM4E | |
| SCHEMBL30228313 | 0.79 | KCNA3 (0.40) | KCNA3CA12CA9ALDH1A1KDM4E | |
| SCHEMBL30228347 | 0.79 | CA12 (0.47) | KCNA3CA12CA9CA1ALDH1A1 | |
| SCHEMBL30228197 | 0.79 | KCNA3 (0.45) | KCNA3CA12CA9ALDH1A1KDM4E | |
| SCHEMBL30228285 | 0.79 | KCNA3 (0.45) | KCNA3CA12CA9ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |