Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870468 | 1.00 | PDE4B (0.37) | PDE4BCNR2CYP3A4MCHR1ACKR3 | |
| SCHEMBL871970 | 0.95 | PDE4B (0.37) | PDE4BCNR2CYP3A4ACKR3TNIK | |
| SCHEMBL4235029 | 0.95 | PDE4B (0.37) | PDE4BCNR2CYP3A4ACKR3TNIK | |
| SCHEMBL871058 | 0.94 | PDE4B (0.39) | PDE4BCNR2CYP3A4MCHR1ACKR3 | |
| SCHEMBL3029859 | 0.94 | PDE4B (0.39) | PDE4BCNR2CYP3A4MCHR1ACKR3 | |
| SCHEMBL3026679 | 0.94 | PDE4B (0.37) | PDE4BCNR2CYP3A4ACKR3TNIK | |
| SCHEMBL3030799 | 0.94 | PDE4B (0.40) | PDE4BCNR2CYP3A4MCHR1ACKR3 | |
| SCHEMBL871091 | 0.94 | PDE4B (0.37) | PDE4BCNR2CYP3A4ACKR3TNIK | |
| SCHEMBL870855 | 0.94 | PDE4B (0.40) | PDE4BCNR2CYP3A4MCHR1ACKR3 | |
| SCHEMBL871760 | 0.93 | ACVR1 (0.38) | PDE4BCNR2CYP3A4TNIKAVPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | PDE4B 2/4885CNR2 2229/4885CYP3A4 116/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | PDE4B 2/4885CNR2 3682/4885CYP3A4 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.