Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023413 | 1.00 | GRIN2B (0.39) | GRIN2BGRIN1PDE4BPDE4DPDE4A | |
| SCHEMBL10271505 | 0.90 | PIK3CA (0.40) | GRIN2BGRIN1MGLLBTKTNF | |
| SCHEMBL8176241 | 0.90 | PIK3CA (0.40) | GRIN2BGRIN1MGLLBTKTNF | |
| SCHEMBL3030831 | 0.89 | PDE4B (0.40) | GRIN2BGRIN1PDE4BPDE4DPDE4A | |
| SCHEMBL3030829 | 0.89 | PDE4B (0.40) | GRIN2BGRIN1PDE4BPDE4DPDE4A | |
| SCHEMBL3916330 | 0.89 | PDE4B (0.34) | GRIN2BGRIN1PDE4BPDE4DPDE4A | |
| SCHEMBL4233037 | 0.89 | PDE4B (0.36) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL4233040 | 0.89 | PDE4B (0.36) | PDE4BPDE4DPDE4APDE4CTNF | |
| SCHEMBL870247 | 0.88 | RIPK2 (0.35) | GRIN2BGRIN1PDE4BPDE4DMGLL | |
| SCHEMBL870246 | 0.88 | RIPK2 (0.35) | GRIN2BGRIN1PDE4BPDE4DMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-B1 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ALCON RES LTD (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | ALCON RESEARCH, LTD. | 2010-08-12 | — | — | US | disclosed |
| US-20090124596-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124596-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | GRIN2B 3964/4885GRIN1 3962/4885PDE4B 2/4885 |
| US-20100204203-A1 | Chemical Compounds 637: Pyridopyrimidinediones as PDE4 Inhibitors | PDE4A, PDE4B, PDE5A | GRIN2B 4188/4885GRIN1 4394/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.