Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.58 |
| ▸ | BRAF | P15056 | 14/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | KRAS | P01116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29272354 | 1.00 | RAF1 (0.58) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL30236478 | 0.95 | RAF1 (0.58) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL29272204 | 0.95 | RAF1 (0.58) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL30236502 | 0.94 | BRAF (0.60) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL29272241 | 0.94 | BRAF (0.60) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL30236949 | 0.91 | BRAF (0.49) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL29272420 | 0.91 | BRAF (0.49) | RAF1BRAFKDRMAPK14MAPK13 | |
| SCHEMBL29272355 | 0.90 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL30236246 | 0.90 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL30236315 | 0.89 | BRAF (0.59) | RAF1BRAFKDRMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |