Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 1.00 |
| ▸ | VEGFA | P15692 | 8/20 | 1.00 |
| ▸ | FLT1 | P17948 | 8/20 | 1.00 |
| ▸ | EGLN3 | Q9H6Z9 | 8/20 | 1.00 |
| ▸ | TET3 | O43151 | 1/20 | 0.77 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.77 |
| ▸ | ASPH | Q12797 | 1/20 | 0.77 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.77 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.77 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.77 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.77 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.77 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921042 | 1.00 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL15164149 | 0.88 | EGLN1 (0.80) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL1921190 | 0.88 | EGLN1 (0.78) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL30239165 | 0.88 | EGLN1 (0.78) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL3484933 | 0.87 | EGLN1 (0.78) | EGLN1VEGFAFLT1EGLN3TET3 | |
| Vadadustat SCHEMBL29357486 | 0.87 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| Vadadustat SCHEMBL1920738 | 0.87 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| Vadadustat SCHEMBL29405970 | 0.87 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL21390798 | 0.87 | EGLN1 (0.82) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL30239178 | 0.86 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3TET3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4095127-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |