Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 11/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | APOL1 | O14791 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23906073 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23884432 | 1.00 | TLR9 (0.36) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23905416 | 0.87 | MAPK1 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL25219176 | 0.87 | MAPK1 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL25219174 | 0.87 | MAPK1 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23906173 | 0.87 | LRRK2 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL30251796 | 0.86 | LRRK2 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23884537 | 0.85 | TLR9 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23906041 | 0.85 | TLR9 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 | |
| SCHEMBL23884535 | 0.85 | TLR9 (0.37) | TLR9TLR8TLR7LRRK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |