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SCHEMBL30255063

SCHEMBL30255063

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C

nearest known ligand 0.80

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PTH1R Q03431 11/20 0.80
▸ GLP1R P43220 7/20 0.68
▸ CCKBR P32239 1/20 0.67
▸ KEAP1 Q14145 1/20 0.67
▸ RXFP1 Q9HBX9 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28980125 1.00 PTH1R (0.80) PTH1RGLP1RCCKBRKEAP1RXFP1
Teriparatide SCHEMBL30645329 1.00 PTH1R (0.80) PTH1RGLP1RCCKBRKEAP1RXFP1
Teriparatide SCHEMBL30448707 1.00 PTH1R (0.80) PTH1RGLP1RCCKBRKEAP1RXFP1
Teriparatide SCHEMBL29394193 1.00 PTH1R (0.80) PTH1RGLP1RCCKBRKEAP1RXFP1
SCHEMBL30975122 0.98 PTH1R (0.78) PTH1RGLP1RCCKBRKEAP1RXFP1
SCHEMBL30449343 0.98 PTH1R (0.77) PTH1RGLP1RCCKBRKEAP1RXFP1
SCHEMBL30449142 0.98 PTH1R (0.77) PTH1RGLP1RCCKBRKEAP1RXFP1
SCHEMBL30449782 0.97 PTH1R (0.76) PTH1RGLP1RCCKBRKEAP1RXFP1
Teriparatide SCHEMBL29357752 0.97 PTH1R (0.85) PTH1RGLP1RCCKBR
SCHEMBL30449150 0.97 PTH1R (0.76) PTH1RGLP1RCCKBRKEAP1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057142-B Purification method of teriparatide 深圳市健元医药科技有限公司 2023-08-29 — — CN disclosed
CN-114560924-B Selenium-containing teriparatide and fusion polypeptide for promoting osteoblast differentiation and application thereof 华南理工大学 2023-06-20 — — CN disclosed
CN-109879954-B Synthetic method of teriparatide 哈尔滨吉象隆生物技术有限公司 2023-03-31 — — CN disclosed
CN-115594754-A Preparation method of teriparatide 前沿生物药业（南京）股份有限公司（CN） 2023-01-13 — — CN disclosed