Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 4/20 | 0.57 |
| ▸ | PPARA | Q07869 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | PPARD | Q03181 | 2/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10952114 | 0.90 | ATM (0.62) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL7279574 | 0.90 | ATM (0.68) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL8829866 | 0.90 | CYP1A2 (0.59) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL6890593 | 0.90 | CYP1A2 (0.59) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL18589486 | 0.88 | PPARG (0.56) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL18607816 | 0.88 | PPARG (0.56) | ATMPPARGPPARACYP3A4APP | |
| SCHEMBL7239876 | 0.84 | ATM (0.67) | ATMCYP3A4APPACECTSS | |
| SCHEMBL6896458 | 0.84 | ATM (0.67) | ATMCYP3A4APPACECTSS | |
| SCHEMBL13770955 | 0.84 | ATM (0.67) | ATMCYP3A4APPACECTSS | |
| SCHEMBL23168374 | 0.83 | ATM (0.65) | ATMCYP3A4APPACECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023043836-A1 | HSD17B13 INHIBITORS AND USES THEREOF | METACRINE, INC. (US) | 2023-03-23 | — | — | WO | disclosed |