Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790843 | 0.87 | NOTUM (0.47) | NOTUMEGLN2HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1696198 | 0.84 | NOTUM (0.47) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL302446 | 0.78 | HCRTR1 (0.46) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL7919899 | 0.78 | NOTUM (0.47) | NOTUMEGLN2HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL17910087 | 0.77 | HCRTR1 (0.43) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL15520028 | 0.77 | NOTUM (0.50) | NOTUMMAPK9MAPK10ALDH1A1 | |
| SCHEMBL29492035 | 0.76 | HCRTR1 (0.41) | NOTUMHCRTR1HCRTR2CYP3A4MAPK9 | |
| SCHEMBL29415179 | 0.76 | DHODH (0.42) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL302594 | 0.75 | HCRTR1 (0.40) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 | |
| SCHEMBL16666145 | 0.73 | NOTUM (0.46) | NOTUMHCRTR1HCRTR2MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4850824-B2 | — | — | 2012-01-11 | — | — | JP | claimed |
| EP-1725544-A1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-11-29 | — | — | EP | claimed |
| WO-2005090333-A1 | 3-‘4-HETEROCYCLYL -1,2,3,-TRIAZOL-1-YL!-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | WO | claimed |
| EP-1567507-A1 | 1,2,3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-08-31 | — | — | EP | claimed |
| WO-2004050642-A1 | 1, 2, 3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-06-17 | — | — | WO | claimed |
| EP-1567507-A1 | 1,2,3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050642-A1 | 1, 2, 3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-06-17 | — | — | WO | disclosed |