Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.57 |
| ▸ | ROS1 | P08922 | 10/20 | 0.57 |
| ▸ | FLT3 | P36888 | 10/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.57 |
| ▸ | EML4 | Q9HC35 | 9/20 | 0.57 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25562810 | 0.85 | RET (0.62) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25252177 | 0.84 | RET (0.59) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562824 | 0.83 | RET (0.61) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562828 | 0.82 | RET (0.57) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562798 | 0.82 | EGFR (0.58) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25561917 | 0.82 | RET (0.70) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562819 | 0.82 | RET (0.57) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25561900 | 0.82 | EGFR (0.60) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562826 | 0.81 | RET (0.56) | RETROS1FLT3ALKEML4 | |
| SCHEMBL25562820 | 0.81 | RET (0.62) | RETROS1FLT3ALKEML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115698000-A | Novel pyrazine compounds | 微境生物医药科技(上海)有限公司 | 2023-02-03 | — | — | CN | disclosed |