Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | KDR | P35968 | 11/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 10/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.61 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.61 |
| ▸ | FLT1 | P17948 | 8/20 | 0.61 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | RET | P07949 | 3/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.60 |
| ▸ | EPHA4 | P54764 | 2/20 | 0.60 |
| ▸ | BTK | Q06187 | 2/20 | 0.60 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16075706 | 0.88 | EGFR (0.67) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL30792543 | 0.87 | EGFR (0.66) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL29453257 | 0.87 | EGFR (0.70) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL30459542 | 0.87 | EGFR (0.70) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL14843536 | 0.87 | EGFR (0.70) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL19124462 | 0.87 | EGFR (0.66) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL21541684 | 0.87 | EGFR (0.66) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL30264723 | 0.87 | EGFR (0.63) | EGFRKDREPHA2ERBB2EPHB4 | |
| SCHEMBL19124214 | 0.86 | EGFR (0.67) | EGFRKDREPHA2ERBB2EPHB4 | |
| Hydrochloric Acid SCHEMBL28028283 | 0.86 | EGFR (0.65) | EGFRKDREPHA2ERBB2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392423-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | Arthrosi Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023028054-A1 | QUINAZOLINE COMPOUNDS FOR TREATMENT OF DISEASE | ARTHROSI THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |