Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.72 |
| ▸ | SYK | P43405 | 2/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.72 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.72 |
| ▸ | FES | P07332 | 1/20 | 0.58 |
| ▸ | FER | P16591 | 1/20 | 0.58 |
| ▸ | FRK | P42685 | 1/20 | 0.58 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.58 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1617807 | 1.00 | TYK2 (0.72) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL3560513 | 0.90 | PIK3CA (0.66) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL11929833 | 0.86 | TYK2 (0.72) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL3110596 | 0.86 | TYK2 (0.75) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL12634088 | 0.85 | TYK2 (0.70) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL1877075 | 0.84 | TYK2 (0.68) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL31025329 | 0.84 | TYK2 (1.00) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL1616481 | 0.84 | TYK2 (1.00) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL30273130 | 0.84 | TYK2 (1.00) | TYK2SYKIRAK4BRSK1FES | |
| SCHEMBL1617732 | 0.83 | TYK2 (0.61) | TYK2SYKIRAK4BRSK1FES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113683596-B | Pyrimidine tankyrase 2 inhibitor and preparation method and application thereof | 上海应用技术大学 | 2023-02-10 | — | — | CN | claimed |
| CN-113683596-B | Pyrimidine tankyrase 2 inhibitor and preparation method and application thereof | 上海应用技术大学 | 2023-02-10 | — | — | CN | disclosed |