Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.58 |
| ▸ | LATS1 | O95835 | 1/20 | 0.58 |
| ▸ | PAK4 | O96013 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | YES1 | P07947 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21055412 | 0.81 | AURKA (0.69) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL4778155 | 0.77 | FLT3 (0.61) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL13987435 | 0.76 | FLT3 (0.60) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL13987478 | 0.75 | AURKA (0.69) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL13987799 | 0.75 | AURKA (0.69) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL20068249 | 0.75 | AURKA (0.75) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL17470164 | 0.75 | AURKA (0.75) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL14396960 | 0.75 | AURKA (0.75) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL14502699 | 0.74 | FLT3 (0.67) | AURKABMPR1BPLK4CITCHEK1 | |
| SCHEMBL19438926 | 0.74 | AURKA (0.61) | AURKABMPR1BPLK4CITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396191-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023033740-A9 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-12-28 | — | — | WO | disclosed |
| WO-2023033740-A1 | COMPOUNDS USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-03-09 | — | — | WO | disclosed |