Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.60 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30278421 | 0.92 | KRAS (0.61) | KRASMAPK3MAPK1 | |
| SCHEMBL29680132 | 0.86 | KRAS (0.57) | KRASMAPK3MAPK1 | |
| SCHEMBL30278416 | 0.85 | KRAS (0.61) | KRASMAPK3MAPK1 | |
| SCHEMBL29680430 | 0.84 | KRAS (0.52) | KRASMAPK3MAPK1 | |
| SCHEMBL29681035 | 0.84 | KRAS (0.60) | KRASMAPK3MAPK1 | |
| SCHEMBL31618676 | 0.82 | KRAS (0.56) | KRAS | |
| SCHEMBL29680635 | 0.82 | KRAS (0.54) | KRASMAPK3MAPK1 | |
| SCHEMBL29681229 | 0.82 | KRAS (0.65) | KRASMAPK3MAPK1 | |
| SCHEMBL31169868 | 0.81 | KRAS (0.66) | KRASMAPK3MAPK1 | |
| SCHEMBL29680542 | 0.81 | KRAS (0.63) | KRASMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384160-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023018812-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2023-02-16 | — | — | WO | disclosed |