Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 10/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24006095 | 1.00 | MAPKAPK2 (0.44) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL24010183 | 0.91 | KDR (0.47) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL23999396 | 0.91 | MAPKAPK2 (0.52) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL24003905 | 0.87 | KDR (0.58) | MAPKAPK2KDRRAF1BRAFPKN1 | |
| SCHEMBL30287670 | 0.87 | KDR (0.58) | MAPKAPK2KDRRAF1BRAFPKN1 | |
| SCHEMBL24006108 | 0.87 | KDR (0.58) | MAPKAPK2KDRRAF1BRAFPKN1 | |
| SCHEMBL25850556 | 0.85 | GAK (0.44) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL24010188 | 0.84 | ABCG2 (0.41) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL24010186 | 0.83 | MAPKAPK2 (0.44) | MAPKAPK2KDRGAKRIPK2COQ8A | |
| SCHEMBL24006251 | 0.82 | KDR (0.46) | MAPKAPK2KDRGAKRIPK2COQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426289-A1 | AKT3 MODULATORS | Georgiamune Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-118574610-A | AKT3 modulators | 乔治穆内公司 | 2024-08-30 | — | — | CN | disclosed |
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115996721-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115867266-A | AKT3 modulators | 乔治穆内有限责任公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-4146185-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |
| EP-4146212-A1 | AKT3 MODULATORS | Georgiamune LLC (US) | 2023-03-15 | — | — | EP | disclosed |