Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289015 | 0.95 | DDB1 (0.51) | DDB1CRBNDRD2IKZF2HDAC8 | |
| SCHEMBL30289258 | 0.87 | CRBN (0.53) | DDB1CRBNDRD2 | |
| SCHEMBL23832611 | 0.87 | CRBN (0.52) | DDB1CRBNDRD2 | |
| SCHEMBL23832546 | 0.87 | CRBN (0.52) | DDB1CRBNDRD2 | |
| SCHEMBL30289503 | 0.86 | DDB1 (0.56) | DDB1CRBN | |
| SCHEMBL23832650 | 0.85 | CRBN (0.48) | DDB1CRBNDRD2 | |
| SCHEMBL23541014 | 0.84 | DDB1 (0.53) | DDB1CRBNDRD2 | |
| SCHEMBL23540613 | 0.84 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL27067107 | 0.84 | CRBN (0.47) | DDB1CRBNDRD2 | |
| SCHEMBL31553801 | 0.83 | DDB1 (0.51) | DDB1CRBNIKZF2HDAC8IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |