Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 8/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30289493 | 0.98 | DDB1 (0.55) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL30289081 | 0.97 | DDB1 (0.54) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL30289475 | 0.93 | DDB1 (0.56) | DDB1CRBNPARP1PARP2DRD2 | |
| SCHEMBL26099950 | 0.91 | DDB1 (0.52) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL26100681 | 0.91 | DDB1 (0.52) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL23832582 | 0.91 | CRBN (0.49) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL30289386 | 0.91 | DDB1 (0.54) | DDB1CRBNPARP1PARP2DRD2 | |
| SCHEMBL26102788 | 0.90 | DDB1 (0.51) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL26098410 | 0.90 | DDB1 (0.51) | DDB1CRBNPARP1PARP2AKT1 | |
| SCHEMBL21070822 | 0.90 | CRBN (0.51) | DDB1CRBNPARP1PARP2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |