Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13055395 | 0.86 | TDP1 (0.55) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL25531030 | 0.81 | TDP1 (0.50) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL17209068 | 0.80 | TDP1 (0.49) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL5327354 | 0.80 | TDP1 (0.57) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL14877947 | 0.80 | CA12 (0.49) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL1979026 | 0.79 | TDP1 (0.55) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL18478942 | 0.79 | TDP1 (0.47) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL8286297 | 0.79 | TDP1 (0.47) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL1404486 | 0.79 | MEN1 (0.49) | TDP1NPSR1MEN1GAAKMT2A | |
| SCHEMBL1584879 | 0.79 | TDP1 (0.47) | TDP1NPSR1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |