Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 19/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 19/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731195 | 0.92 | DDB1 (0.58) | DDB1CRBN | |
| SCHEMBL23540958 | 0.88 | CRBN (0.53) | DDB1CRBN | |
| SCHEMBL23540613 | 0.86 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL23540810 | 0.85 | CRBN (0.56) | DDB1CRBN | |
| SCHEMBL23541163 | 0.84 | DDB1 (0.60) | DDB1CRBN | |
| SCHEMBL26101041 | 0.83 | DDB1 (0.52) | DDB1CRBN | |
| SCHEMBL26101026 | 0.83 | CRBN (0.54) | DDB1CRBN | |
| SCHEMBL31397374 | 0.82 | DDB1 (0.51) | DDB1CRBN | |
| SCHEMBL30273602 | 0.82 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL26101435 | 0.82 | DDB1 (0.47) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |