Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HINT1 | P49773 | 5/20 | 0.68 |
| ▸ | NT5E | P21589 | 1/20 | 0.62 |
| ▸ | GSK3A | P49840 | 2/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | PNP | P00491 | 2/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL27904526 | 0.95 | HPGD (0.73) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL278157 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL5550180 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL12959061 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL24049608 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL24049417 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL24049416 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL24049467 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL20750695 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| Guanosine SCHEMBL7062800 | 0.95 | HPGD (0.76) | HPGDHINT1NT5EGSK3ARPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813006-A | Methods for controlling diamide-resistant pests and compounds thereof | 先正达农作物保护股份公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117715523-A | Methods for controlling diamide-resistant pests and compounds thereof | 先正达农作物保护股份公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117642385-A | Pesticidally active cyclic amine compounds | 先正达农作物保护股份公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117561252-A | 2- [3- [1[ (quinazolin-4-yl) amino ] ethyl ] pyrazin-2-yl ] thiazole-5-carbonitrile derivatives and similar compounds as pesticides | 先正达农作物保护股份公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117529477-A | Pesticidally active diazine-amide compounds | 先正达农作物保护股份公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117412961-A | Pesticidally active heteroaromatic compounds | 先正达农作物保护股份公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117157287-A | Pesticidally active cyclic amine compounds | 先正达农作物保护股份公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-116783193-A | Pesticidally active heterocyclic derivatives with sulfur containing substituents | 先正达农作物保护股份公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116234811-A | Pesticidally active heterocyclic derivatives with sulfur containing substituents | 先正达农作物保护股份公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116075226-A | Pesticidally active heterocyclic derivatives with sulfur containing substituents | 先正达农作物保护股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-116056577-A | Pesticidally active heterocyclic derivatives with sulfur containing substituents | 先正达农作物保护股份公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-116018344-A | Pesticidally active heterocyclic derivatives with sulfur containing substituents | 先正达农作物保护股份公司 | 2023-04-25 | — | — | CN | disclosed |