Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 6/20 | 0.46 |
| ▸ | CDK1 | P06493 | 5/20 | 0.46 |
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 5/20 | 0.46 |
| ▸ | CCND3 | P30281 | 5/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CDK7 | P50613 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | CCNH | P51946 | 4/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | TYK2 | P29597 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291343 | 0.90 | CCNE1 (0.55) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291250 | 0.75 | CCNE1 (0.55) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291164 | 0.73 | CCNE1 (0.37) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291204 | 0.71 | JAK2 (0.40) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291206 | 0.71 | JAK2 (0.40) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291203 | 0.71 | JAK2 (0.40) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291151 | 0.71 | JAK2 (0.40) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL30291155 | 0.71 | JAK2 (0.40) | CCNE1CDK2CDK1CDK4CCNB1 | |
| SCHEMBL17187759 | 0.70 | AR (0.39) | JAK2JAK1TYK2JAK3FFAR1 | |
| SCHEMBL30810412 | 0.69 | CDK1 (0.51) | CCNE1CDK2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355742-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | Blueprint Medicines Corporation (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-117813300-A | Substituted pyrimidinyl-pyrazoles as CDK2 inhibitors | 缆图药品公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022266190-A1 | SUBSTITUTED PYRIMIDINYL-PYRAZOLES AS CDK2 INHIBITORS | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-22 | — | — | WO | disclosed |