Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.73 |
| ▸ | DDB1 | Q16531 | 11/20 | 0.73 |
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | IL1B | P01584 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.59 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.59 |
| ▸ | CCNK | O75909 | 1/20 | 0.57 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713150 | 1.00 | CRBN (0.73) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL30281888 | 1.00 | CRBN (0.73) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL29839634 | 1.00 | CRBN (0.73) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL30293948 | 1.00 | CRBN (0.73) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL31655709 | 0.99 | CRBN (0.72) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL23832857 | 0.92 | CRBN (0.77) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL19692297 | 0.92 | CRBN (0.77) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL21294522 | 0.92 | CRBN (0.77) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL22959658 | 0.92 | CRBN (0.77) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL19692342 | 0.92 | CRBN (0.77) | CRBNDDB1STAT3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419518-A1 | SMALL MOLECULES FOR DOT1L DEGRADATION AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023069348-A1 | SMALL MOLECULES FOR DOT1L DEGRADATION AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-27 | — | — | WO | disclosed |