Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | CTSC | P53634 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484330 | 1.00 | EGFR (0.47) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL21484289 | 0.92 | EGFR (0.50) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL21484353 | 0.91 | EGFR (0.49) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL21484393 | 0.91 | EGFR (0.42) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL23049191 | 0.90 | KIT (0.47) | EGFRCSF1RKITEIF2AK2GSK3B | |
| SCHEMBL20150874 | 0.90 | JAK3 (0.56) | EGFRBTKJAK3CSF1R | |
| SCHEMBL21516226 | 0.90 | JAK3 (0.49) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL21484328 | 0.89 | EGFR (0.47) | EGFRBTKJAK3CSF1RCTSC | |
| SCHEMBL21484339 | 0.89 | EGFR (0.49) | EGFRBTKJAK3CTSCKIT | |
| SCHEMBL21484311 | 0.87 | EGFR (0.47) | EGFRBTKJAK3CSF1RCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11608334-B2 | Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof | The National Institutes of Pharmaceutical R&D Co., Ltd. (CN) | 2023-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11608334-B2 | Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof | BTK, SYK, ITK | EGFR 1705/4885BTK 1/4885JAK3 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.