Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26981001 | 1.00 | PTPN11 (0.79) | PTPN11KCNH2EGFR | |
| SCHEMBL21115042 | 1.00 | PTPN11 (0.79) | PTPN11KCNH2EGFR | |
| SCHEMBL21154416 | 0.95 | PTPN11 (0.76) | PTPN11KCNH2EGFR | |
| SCHEMBL19785589 | 0.92 | PTPN11 (0.81) | PTPN11KCNH2EGFR | |
| SCHEMBL30295728 | 0.92 | PTPN11 (0.81) | PTPN11KCNH2EGFR | |
| SCHEMBL19785614 | 0.90 | PTPN11 (0.80) | PTPN11KCNH2EGFR | |
| SCHEMBL30295924 | 0.90 | PTPN11 (0.80) | PTPN11KCNH2EGFR | |
| SCHEMBL25261253 | 0.90 | PTPN11 (0.75) | PTPN11KCNH2EGFR | |
| SCHEMBL21154584 | 0.89 | PTPN11 (0.86) | PTPN11KCNH2EGFR | |
| SCHEMBL21115105 | 0.89 | PTPN11 (0.73) | PTPN11KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478132-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |