Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785386 | 1.00 | PTPN11 (0.67) | PTPN11KCNH2EGFR | |
| SCHEMBL21115201 | 1.00 | PTPN11 (0.67) | PTPN11KCNH2EGFR | |
| SCHEMBL25514939 | 0.91 | PTPN11 (0.67) | PTPN11KCNH2EGFR | |
| SCHEMBL21115211 | 0.86 | PTPN11 (0.50) | PTPN11KCNH2EGFR | |
| SCHEMBL19785372 | 0.85 | PTPN11 (0.49) | PTPN11KCNH2EGFR | |
| SCHEMBL21115224 | 0.84 | PTPN11 (0.72) | PTPN11KCNH2EGFR | |
| SCHEMBL19785500 | 0.84 | PTPN11 (0.72) | PTPN11KCNH2EGFR | |
| SCHEMBL30295968 | 0.84 | PTPN11 (0.72) | PTPN11KCNH2EGFR | |
| SCHEMBL23186770 | 0.83 | PTPN11 (0.69) | PTPN11KCNH2EGFR | |
| SCHEMBL21154402 | 0.83 | PTPN11 (0.74) | PTPN11KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478132-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |