Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.65 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19785336 | 1.00 | PTPN11 (0.65) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30295870 | 0.91 | PTPN11 (0.80) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785300 | 0.91 | PTPN11 (0.80) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL25514349 | 0.90 | PTPN11 (0.53) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL23425127 | 0.86 | PTPN11 (0.50) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30296115 | 0.86 | PTPN11 (0.65) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL19785338 | 0.86 | PTPN11 (0.65) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL21154819 | 0.83 | PTPN11 (0.54) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL24233637 | 0.82 | PTPN11 (0.52) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL30296123 | 0.81 | PTPN11 (0.80) | PTPN11KCNH2MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478131-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478132-A | 2, 5-disubstituted and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-109983001-B | 2, 5-disubstituted 3-methylpyrazines and 2,5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |