Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 15/20 | 0.79 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.79 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25083933 | 1.00 | EDNRA (0.79) | EDNRAAGTR1AGTR2ACHEABCC3 | |
| SCHEMBL29706567 | 0.94 | EDNRA (0.81) | EDNRAAGTR1AGTR2 | |
| SCHEMBL4773488 | 0.94 | EDNRA (0.81) | EDNRAAGTR1AGTR2 | |
| SCHEMBL25084274 | 0.93 | EDNRA (0.74) | EDNRAAGTR1AGTR2ACHEABCC3 | |
| SCHEMBL30295915 | 0.93 | EDNRA (0.74) | EDNRAAGTR1AGTR2ACHEABCC3 | |
| SCHEMBL4767402 | 0.89 | EDNRA (0.78) | EDNRAAGTR1AGTR2 | |
| SCHEMBL25084451 | 0.89 | EDNRA (0.78) | EDNRAAGTR1AGTR2ACHE | |
| Sparsentan SCHEMBL29706489 | 0.89 | EDNRA (1.00) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| Sparsentan SCHEMBL535109 | 0.89 | EDNRA (1.00) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL25083861 | 0.88 | EDNRA (0.81) | EDNRAAGTR1AGTR2ACHELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023025277-A1 | AROMATIC RING-CONTAINING BIOLOGICAL ANTAGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2023-03-02 | — | — | WO | disclosed |