Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.61 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.55 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25293325 | 1.00 | SYK (0.61) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL25294083 | 0.89 | SYK (0.62) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL30299474 | 0.89 | SYK (0.62) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL30299675 | 0.88 | SYK (0.59) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL25290754 | 0.88 | SYK (0.59) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL25292732 | 0.86 | SYK (0.73) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL30299547 | 0.86 | SYK (0.73) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL25248577 | 0.85 | SYK (0.74) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL30338411 | 0.85 | SYK (0.74) | SYKBTKJAK2NTRK1ROS1 | |
| SCHEMBL30299567 | 0.85 | SYK (0.60) | SYKBTKJAK2NTRK1ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157848-A1 | COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS | Nanjing Ruijie Pharma Co., Ltd. (CN) | 2023-04-05 | — | — | EP | claimed |
| CN-115916782-B | Compounds and their use as inhibitors of spleen tyrosine kinase | 南京瑞捷医药科技有限公司 | 2024-08-13 | — | — | CN | disclosed |
| EP-4157848-A1 | COMPOUNDS AND THEIR USES AS SPLEEN TYROSINE KINASE INHIBITORS | Nanjing Ruijie Pharma Co., Ltd. (CN) | 2023-04-05 | — | — | EP | disclosed |
| CN-115916782-A | Compounds and their use as spleen tyrosine kinase inhibitors | 南京瑞捷医药科技有限公司 | 2023-04-04 | — | — | CN | disclosed |