Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.36 |
| ▸ | FYN | P06241 | 4/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22678008 | 1.00 | FGFR1 (0.68) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL30303784 | 0.92 | FGFR1 (0.80) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL22675743 | 0.92 | FGFR1 (0.80) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL22676682 | 0.92 | FGFR1 (0.72) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL30303646 | 0.92 | FGFR1 (0.72) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL22676895 | 0.89 | FGFR1 (0.86) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL30303773 | 0.89 | FGFR1 (0.86) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL22676218 | 0.88 | FGFR1 (0.62) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL22675735 | 0.87 | FGFR1 (0.68) | FGFR1FGFR3FGFR2FGFR4CYP3A4 | |
| SCHEMBL30303723 | 0.87 | FGFR1 (0.68) | FGFR1FGFR3FGFR2FGFR4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12522605-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2026-01-13 | — | — | US | disclosed |
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | RELAY THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230192709-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230104574-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | D.E. SHAW RESEARCH, LLC | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192709-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR3 1/4885FGFR2 2/4885 |
| US-20230104574-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR3 1/4885FGFR2 2/4885 |
| US-11780845-B2 | FGFR inhibitors and methods of use thereof | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR3 1/4885FGFR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.