Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.67 |
| ▸ | TNF | P01375 | 2/20 | 0.67 |
| ▸ | IL1B | P01584 | 2/20 | 0.67 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26102151 | 1.00 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25011614 | 0.88 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL26058032 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31444087 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24779883 | 0.86 | CRBN (0.56) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25011325 | 0.85 | CRBN (0.57) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL17724153 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25012124 | 0.85 | CRBN (0.55) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL17724152 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL17724079 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023056443-A1 | BINDERS OF CEREBLON AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-04-06 | — | — | WO | disclosed |