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Sugi Predict / Compounds / Trifluoroacetic Acid

Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL30304367

CNCCCc1ccc2c(c1)n(C)c(=O)n2C1CCC(=O)NC1=O.O=C(O)C(F)(F)F

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 18/20 0.66
▸ DDB1 Q16531 15/20 0.66
▸ GRIN2B Q13224 1/20 0.35
▸ GSPT1 P15170 3/20 0.34
▸ IKZF2 Q9UKS7 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21070670 0.92 CRBN (0.77) CRBNDDB1GRIN2B
Hydrochloric Acid SCHEMBL30258170 0.91 CRBN (0.76) CRBNDDB1GRIN2B
SCHEMBL23832535 0.88 CRBN (0.74) CRBNDDB1
Trifluoroacetic Acid SCHEMBL27135984 0.88 CRBN (0.58) CRBNDDB1GSPT1IKZF2CYP2C19
Trifluoroacetic Acid SCHEMBL26100281 0.88 CRBN (0.58) CRBNDDB1GSPT1IKZF2CYP2C19
Trifluoroacetic Acid SCHEMBL27131327 0.88 CRBN (0.58) CRBNDDB1GSPT1IKZF2CYP2C19
SCHEMBL31664226 0.88 CRBN (0.71) CRBNDDB1
SCHEMBL21107300 0.88 CRBN (0.71) CRBNDDB1
Trifluoroacetic Acid SCHEMBL25340753 0.86 DDB1 (0.57) CRBNDDB1IKZF2
SCHEMBL21069306 0.86 CRBN (0.71) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023055952-A1 NEUROTROPHIC TYROSINE RECEPTOR KINASE (NTRK) DEGRADING COMPOUNDS C4 THERAPEUTICS, INC. (US) 2023-04-06 — — WO disclosed