SCHEMBL30306173

SCHEMBL30306173

C[Si](C)(C)CCOCN1C(=O)COc2ncc(N3C[C@H](CCNC(=O)O)OC3=O)nc21

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.38
GRM2 Q14416 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23857099 1.00 KCNH2 (0.38) KCNH2GRM2
SCHEMBL31007096 0.90 KCNH2 (0.40) KCNH2
SCHEMBL23857122 0.90 KCNH2 (0.40) KCNH2
SCHEMBL30882951 0.88 KCNH2 (0.36) KCNH2GRM2
SCHEMBL23857119 0.88 KCNH2 (0.36) KCNH2GRM2
Hydrochloric Acid SCHEMBL23856598 0.87 KCNH2 (0.35) KCNH2GRM2
Hydrochloric Acid SCHEMBL23856600 0.87 KCNH2 (0.35) KCNH2GRM2
SCHEMBL23857654 0.84 KCNH2 (0.34) KCNH2
SCHEMBL23857499 0.84 KCNH2 (0.34) KCNH2
SCHEMBL23857398 0.83 KCNH2 (0.34) KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4405352-A1 NEW COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. Hoffmann-La Roche AG (CH) 2024-07-31 EP disclosed
WO-2023041756-A1 NEW COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2023-03-23 WO disclosed