Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 10/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784478 | 1.00 | TSHR (0.44) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL8707829 | 0.81 | PDE4B (0.43) | PDE4B | |
| SCHEMBL5274226 | 0.77 | TSHR (0.41) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL6783812 | 0.76 | TSHR (0.39) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL7175438 | 0.75 | PTGDR2 (0.39) | TSHRPDE4BPTGDR2 | |
| SCHEMBL22946143 | 0.75 | TSHR (0.41) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL5330768 | 0.75 | MRGPRX4 (0.43) | TSHRPTGDR2 | |
| SCHEMBL6788039 | 0.75 | TSHR (0.38) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL1714808 | 0.75 | TSHR (0.39) | TSHRPDE4BPTGDR2CNR2 | |
| SCHEMBL26662458 | 0.75 | PPARA (0.51) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115956075-A | Allosteric enone inhibitors of phosphoinositide 3-kinases (PI 3 ks) for the treatment of diseases associated with PI3K modulation | 佩特拉制药公司 | 2023-04-11 | — | — | CN | disclosed |
| EP-4126851-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION | Petra Pharma Corporation (US) | 2023-02-08 | — | — | EP | disclosed |