Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | FASN | P49327 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394049 | 0.86 | FASN (0.45) | FASNKDM1AMAOBBTKEPHX2 | |
| SCHEMBL2394045 | 0.86 | FASN (0.45) | FASNKDM1AMAOBBTKEPHX2 | |
| SCHEMBL30312921 | 0.79 | USP30 (0.45) | FASNKDM1AMAOBKDM4DBTK | |
| SCHEMBL32677539 | 0.78 | KDM1A (0.50) | KDM1AMAOBKDM4DBTKEPHX2 | |
| SCHEMBL31114455 | 0.76 | EPHX2 (0.59) | KDM1AMAOBEPHX2 | |
| SCHEMBL14780694 | 0.76 | BTK (0.51) | KDM1AMAOBBTKEPHX2DRD2 | |
| SCHEMBL26669722 | 0.76 | BTK (0.51) | KDM1AMAOBBTKEPHX2DRD2 | |
| SCHEMBL5095952 | 0.76 | BTK (0.51) | KDM1AMAOBBTKEPHX2DRD2 | |
| SCHEMBL573140 | 0.75 | BTK (0.48) | KDM1AMAOBBTKEPHX2DRD2 | |
| SCHEMBL573139 | 0.75 | BTK (0.48) | KDM1AMAOBBTKEPHX2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |