Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.54 |
| ▸ | SMO | Q99835 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1732629 | 1.00 | PARP10 (0.69) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL12356722 | 0.91 | PARP10 (0.59) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL14562689 | 0.89 | PARP10 (0.56) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL12356701 | 0.88 | PARP10 (0.55) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL2250280 | 0.88 | PARP10 (0.55) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL975145 | 0.87 | PARP10 (0.54) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL974397 | 0.87 | PARP10 (0.54) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL2248223 | 0.87 | ALOX5AP (0.55) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL978458 | 0.86 | PARP10 (0.53) | PARP10MAPTKDM4EPOLBRAB9A | |
| SCHEMBL1122619 | 0.86 | MAPT (0.64) | PARP10MAPTKDM4EPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161494-A1 | NITROGEN-CONTAINING FUSED BICYCLIC COMPOUNDS AND THEIR USE AS UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 1 (USP1) INHIBITORS | KSQ Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |